Phosphorylation shifts the time-dependence of cardiac Ca++ channel gating currents
نویسندگان
چکیده
منابع مشابه
Simple shifts in the voltage dependence of sodium channel gating caused by divalent cations
The effect of elevated divalent cation concentration on the kinetics of sodium ionic and gating currents was studied in voltage-clamped frog skeletal muscle fibers. Raising the Ca concentration from 2 to 40 mM resulted in nearly identical 30-mV shifts in the time courses of activation, inactivation, tail current decay, and ON and OFF gating currents, and in the steady state levels of inactivati...
متن کاملSubtype-Specific Effects on Ca Channel Gating
Ca channel subunits are important molecular determinants of the kinetics and voltage dependence of Ca channel gating. Through direct interactions with channel-forming 1 subunits, subunits enhance expression levels, accelerate activation, and have variable effects on inactivation. Four distinct subunit genes each encode five homologous sequence domains (D1–5), three of which (D1, D3, and D5) und...
متن کاملSodium channel gating currents. Origin of the rising phase
There has been some uncertainty in the past as to the origin of the rising phase of the gating current. We present evidence here that proves that the gating current does not have a rising phase and that the observed rising phase is due to an uncompensated series resistance in the Frankenhaeuser-Hodgkin (F-H) space. When a squid giant axon is bathed in a solution that is 10-20% hyperosmotic with...
متن کاملThree-Dimensional Simulation of Qeshm Channel Currents
Qeshm Channel is a shallow and narrow waterway located between Qeshm Island and the mainland in the vicinity of Hormuzgan Province, Islamic Republic of Iran. This channel is important because of its economic, industrial, fisheries and navigation role it plays as well as environmental issues it presents in the region. A prognostic study was performed to simulate currents in this channel, using C...
متن کاملPharmacological and kinetic analysis of K channel gating currents
We have measured gating currents from the squid giant axon using solutions that preserve functional K channels and with experimental conditions that minimize Na channel contributions to these currents. Two pharmacological agents were used to identify a component of gating current that is associated with K channels. Low concentrations of internal Zn2+ that considerably slow K channel ionic curre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1991
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(91)82075-6